An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extractsArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis applied approach baicalein binding carried catalytic characteristic Chinese complementary complex Compound Covalent binder Cys145 database drug target electrophilic Final functional HIS163 HIS164 His41 independent inhibitor inhibitors Ion knowledge M pro M(pro) mass mass spectrometry maturation metabolomic metabolomics Michael molecular dynamics MPro nucleophilic peptide platform polyprotein protease protein-ligand Proteins proteomic proteomics residue SARS-CoV-2 SARS-CoV-2. Scutellaria baicalensis tested the SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123824 PMC 바로가기
SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogrammingArticle Published on 2023-01-052023-07-11 Journal: Cell [Category] COVID19(2023년), [키워드] airway epithelial cells cilia COVID-19 microvilli organoids protein kinases proteomics respiratory synctital virus Respiratory virus. SARS-CoV-2 [DOI] 10.1016/j.cell.2022.11.030 PMC 바로가기
Mass spectrometry detection of monkeypox virus: Comprehensive coverage for ranking the most responsive peptide markersArticle Published on 2023-01-012023-06-09 Journal: Proteomics [Category] 원숭이두창, [키워드] detection DIA markers mass spectrometry Monkeypox proteomics virus. [DOI] 10.1002/pmic.202200253 PMC 바로가기
Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumoniaArticle Published on 2022-12-132023-06-20 Journal: Immunity [Category] Fulltext, MERS, [키워드] Actin COVID-19 Degradation DNA DNase I histone Inflammation NETs proteomics sepsis. [DOI] 10.1016/j.immuni.2022.11.007 PMC 바로가기
Clinical microbiology in detection and identification of emerging microbial pathogens: past, present and futureArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] 진단, [키워드] Antibody assays Antigen Bacterial pathogens change clinical clinical microbiology Clinical practice COVID-19 COVID-19 pandemic Critical Culture Diagnosis diagnostics Diseases evidenced Genomics Gram stain IMPROVE in vitro Infectious disease metabolomics microbial microbial infections Molecular biology MONITOR morphology nucleic acid nucleic acid amplification outcome pathogen detection Patient point of care progression proteomics Revolutionary transcriptomics transcriptomics. [DOI] 10.1080/22221751.2022.2125345 PMC 바로가기
The role of multi-omics in the diagnosis of COVID-19 and the prediction of new therapeutic targetsReview Published on 2022-12-012023-07-09 Journal: Virulence [Category] COVID19(2023년), [키워드] COVID-19 Genomics metabolomics Multi-omics proteomics transcriptomic. [DOI] 10.1080/21505594.2022.2092941 PMC 바로가기 [Article Type] Review
The human host response to monkeypox infection: a proteomic case series studyArticle Published on 2022-11-082022-11-16 Journal: EMBO Molecular Medicine [Category] 유전자 메커니즘, [키워드] acute phase response Applying Biomarker case sery CFHR1 complement correlation COVID-19 disease severity Diseases endemic area healthy controls Host host response human host Infection Monkeypox virus outbreak overlap Patient plasma plasma protein Protein Proteins proteome proteomic proteomics provided Research similarities suggested suppressed the disease viral infection Viral infection. [DOI] 10.15252/emmm.202216643 PMC 바로가기
A Meta-summary and Bioinformatic Analysis Identified Interleukin 6 as a Master Regulator of COVID-19 Severity BiomarkersResearch article Published on 2022-11-012022-10-05 Journal: Cytokine [Category] 바이오마커, 임상, 진단, 치료기술, [키워드] addition approach Bioinformatic Bioinformatics analysis Biomarker Biomarkers candidate Compound conserved COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity Cytokine storm Cytokines dataset datasets disease severity enriched biological processe extreme highlight Identified identify IL6 immunological reaction include Inflammatory biomarker Inflammatory response interleukin 6 Isolation neurological Patient physiological system Prognosis Prognostic markers progression Protein proteomics regulator rising robust screening methods severity therapeutic approach Therapeutic approach treating COVID-19 Treatment upstream validation study [DOI] 10.1016/j.cyto.2022.156011 [Article Type] Research article
Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in miceArticle Published on 2022-11-012022-11-15 Journal: Inflammation research : official journal of the Eu [Category] 유전자 메커니즘, 진단, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome alleviate Analysis Anti-inflammatory anti-inflammatory property anti-inflammatory response ARDS CFZ Clofazimine coronavirus disease COVID-19 Critical decrease disease Diseases distress down-regulate histological change hyperimmune response IL-1β immune IMPROVE increasingly Infectious disease Inflammatory information inhibit involved lipopolysaccharide LPS lung Lung injury Macrophage macrophages mechanism mice Molecular biology pathway pharmacological mechanism potential molecular profile proliferation protective effect Protein protein expression Proteomic analysis proteomics proteomics. Pulmonary edema Quantitative Signal transduction Signaling significantly survival rate syndrome therapeutic strategy TNF-α [DOI] 10.1007/s00011-022-01623-w PMC 바로가기
Machine learning algorithms based on proteomic data mining accurately predicting the recurrence of hepatitis B-related hepatocellular carcinomaArticle Published on 2022-11-012023-06-13 Journal: Journal of gastroenterology and hepatology [Category] B형 간염, [키워드] CPTAC database machine learning models proteomics recurrence of hepatocellular carcinoma. [DOI] 10.1111/jgh.15940 PMC 바로가기